PREVENT-SCA abstract
MTWA at the European Congress of Cardiology in Barcelona
(August 31- Sept 1st)
Last issues:
The Efficacy of Microvolt T-Wave Alternans Testing and
Other Noninvasive Risk Stratification Methods for Identifying Patients at Risk
of Sudden Cardiac Death (EP Digest June 2009)
US registry points to substantial risk from ICD,
pacemaker replacement
TWA Presentations at HRS 2009 in Boston
Can we alternate between T-wave alternans testing
methods?
Heart
Rhythm, Vol 6, No 3, March 2009
Yale University investigated whether anger-induced MTWA
was associated with risk of arrhythmic events (Jacc March 2009)
February 2009:
Podcast posted on the Heart Rhythm
Journal’s website: Dr. Zipes, editor of
the journal, interviews Dr. Rosenbaum about T wave alternans
– topics include his take on the
MASTER trial and how he uses MTWA in clinical practice:
Click
to Listen http://www.heartrhythmjournal.com/webfiles/images/journals/hrthm/Feb09_David_Rosenbaum_Interview.mp3
From JACC: ABCD trial — T-wave alternans to improve sudden
cardiac death prevention.
Watch a related
CVN video. 
ABCD Trial Key Points
ABCD Trial published
Strategies
Using T-Wave Alternans to Improve Efficiency of Sudden Cardiac Death Prevention
Published (J Am Coll Cardiol
2009;53:471–9)
Editorial: Good results only if MTWA stress / pacing protocols and patient
preparation are the standard ones
POSITIVE MICROVOLT T-WAVE ALTERNANS IS ASSOCIATED WITH
ORGANIC HEART DISEASE IN PATIENTS WITH VENTRICULAR ARRHYTHMIAS AND RIGHT
VENTRICULAR OUTFLOW TRACT PATTERN. (Italian Journal of Electrophysiology
2008 Vol 11, 4: 39)
Impact of Age and Medical Comorbidity on the
Effectiveness of Implantable Cardioverter-Defibrillators for Primary Prevention
(Circulation January 6, 2009Full free on line): no significant differences in the degree of ICD mortality
reduction benefit across age and medical comorbidity subgroups but…
….find
differences in the relative benefit associated with ICD therapy among patients
screening high- and low-risk with MTWA (P=0.02)
2008
SCD-Heft Substudy review paper published in Circulation
Nov 11, Full free on line
SCD-HeFT Substudy Review Summary
SCD-Heft Substudy and MASTER published…Comments
from D. Rosenbaum , P.Chan and T. Chow
NEW : Potentially life-threatening VA (cycle length ≤260
ms) that resulted in appropriate ICD therapy are found to be more than 3 times
the number of appropriate standard ICD Theraphy (J Cardiovasc Electrophysiol.
2008).
The need of a better risk stratification: A critical
appraisal of implantable cardioverter-defibrillator therapy for the prevention
of sudden cardiac death. J Am Coll Cardiol. 2008
Evidence-based framework integrating TWA with other risk
factors to stratify risk for sudden cardiac arrest (Progress in Cardiovascular
Diseases, Vol. 51, No. 2 (September/October), 2008)
T-wave alternans test's prognostic horizon exceeds two
years in analysis (August 1, 2008 issue of the American Journal of
Cardiology.)
Review paper from Dr Theodore Chow( PI of
Master Study)
Expert Commentary from T Chow paper
·
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New Review Paper
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AHA
2005 Studies Demonstrate Effectiveness of Microvolt T-Wave Alternans
in Predicting Sudden Cardiac Death Regardless of Ejection Fraction on 2358
patients
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European Congress of Cardiology August 2008 Munich TWA
presentations
·
TWA presentations at
AHA 2008
·
MTWA at CARDIOSTIM 2008 with related abstracts
·
Biventricular pacing attenuates T-wave alternans and T-wave amplitude compared to other pacing
modes (Pacing Clin Electrophysiol.
2008 Jun)
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New REVIEW paper
·
MTWA at ACC 2008 with abstracts
·
Video from the experience of a MTWA tested patient
·
European
Heart Journal: T-wave alternans predicts mortality in a population undergoing a
clinically indicated exercise test
·
Editorial
on the European Heart Journal: T Wave Alternans: predicting the unpredictable
2007
·
·
MASTER Study discussion on The Heart.org
·
Dr Theodore Chow, Principal Investigator of MASTER I
trial, statement
·
Latest news: ALPHA Study published on JACC on line
·
AHA 2007 Late-Breaking
Clinical Trials:
·
MASTER
I Study results
·
Comments
from TheHeart.org
·
Reference paper to understand the results: Frequency and
causes of implantable cardioverter-defibrillator
therapies: is device therapy proarrhythmic? (Am J.
Card)
·
Editorial: New MTWA studies on ICD patients, end points,
follow up time, indeterminate results and MTWA Stress /EP protocols.
·
·
NEW on Int J. Card: Combined
prognostic value of peak O2 uptake and microvolt level T-wave alternans in patients with idiopathic dilated cardiomyopathy
·
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New paper on PACE :
MTWA on Diabetic Patients:
·
Relationship between abnormal Microvolt T Wave Alternans and poor glycemic
control in type 2 diabetic patients
·
·
New paper on JACC:
·
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Editorial: New MTWA studies on ICD patients, end points,
follow up time, indeterminate results and MTWA Stress /EP protocols.
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Other issues:
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The first European Multicenter Clinical Trial: The ALPHA
(T-Wave Alternans in Patients With Heart Failure)
clinical study late-breaker presentation during plenary session
(theHeart.org)
·
The ALPHA Study and review of the latest MTWA studies at Cardiosource (ACC)
·
Other MTWA presentations at ACC
·
·
2 papers on JACC:
·
Microvolt T-Wave Alternans
Identifies Patients With Ischemic Cardiomyopathy Who
Benefit From Implantable Cardioverter-Defibrillator Therapy
( J Am Coll Cardiol,
2007;49:50-58):
·
-Abstract at JACC
·
-Expert moderated discussion at JACC NEW
·
-Full paper at Medscape
·
-Comments
at TheHeart.org
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Predictive Value of Microvolt T-Wave Alternans
for Sudden Cardiac Death in Patients With Preserved Cardiac Function After
Acute Myocardial Infarction (JACC 2006;48:2268-74)
·
Comments at TheHeart.org
·
ACC/AHA/ESC Guidelines for the Management of Patients
with Ventricular Arrhythmias and the Prevention of Cardiac Death –
Extracted Sections on T Wave Alternans in Class 2a (Level of Evidence A):
All reference papers are based on the Spectral Analytic Method
·
·
Microvolt T-Wave Alternans
(TWA) Testing: Can It Identify Athletes at High Risk of Ventricular Arrhythmias
and Sudden Cardiac Death?
·
Cost-Effectiveness of a Microvolt T-Wave Alternans Screening Strategy for Implantable Cardioverter-Defibrillator Placement in the
MADIT-II–Eligible Population (JACC June 7on line )
·
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MEDICARE
Decision Memo for Microvolt T-wave Alternans
(ONLY Spectral Method) for patients who may need an ICD
·
Comments to the MEDICARE Decision Memo:
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- Editor Comment
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-The Wall Street Journal
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European
Congress of Cardiology Vienna September 2007 ABSTRACTS
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AHA
MTWA Abstracts 2007
·
Heart
Rhythm Society 2007 in Denver :
·
20 MTWA presentations
·
MTWA
Session: T Wave Alternans. Mechanism
and Implications to Clinical Practice
·
Best Clinical MTWA abstracts
·
Italian Congress of
Cardiology (ANMCO) June 5
·
ISHNE
Congress Athens Greece June 7-9
·
MTWA
presentations at EUROPACE – June 2007 in Lisbon
·
New
paper on JACC: Prognostic Utility of Microvolt T-Wave Alternans in Risk
Stratification of Patients With Ischemic Cardiomyopathy
·
Endocardial
and Epicardial Repolarization Alternans in Human Cardiomyopathy - Evidence for
Spatiotemporal Heterogeneity and Correlation With Body Surface T-Wave Alternans
(J Am Coll Cardiol, 2007; 49:338-346)
·
TheHeart.org: Medicare
proposes drastic reductions in reimbursement for cardiovascular procedures ICD implantation would be
reduced by about a quarter… so MTWA could be necessary
·
Medscape: Microvolt T-Wave Alternans Testing and
ICD Risk Stratification: An Expert Interview With Anne B. Curtis, MD President of the Heart Rhythm
Society
·
MTWA at ACC:
Meet the experts Sessions ”T-Wave Alternans Negative Patients Do Not Need an Implantable
Cardioverter Defibrillator” and the
best MTWA abstracts
·
Best T Wave Alternans AHA 2006 abstracts
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The Cost Effectiveness of Implantable
Cardioverter-Defibrillators: Results From the Multicenter Automatic
Defibrillator Implantation Trial (MADIT)-II (JACC 2006;47:2310-2318)
·
Microvolt T-Wave Alternans with Exercise in Pediatrics
and Congenital Heart Disease: Limitations and Predictive Value
·
MTWA Session
at Heart Rhythm 2006 Scientific Sessions (HRS) with abstracts
·
Additional
MTWA sessions and abstracts at HRS
·
CARDIOSTIM
2006( Nice, June 14 - 17 ) MTWA updated presentations with abstracts
·
New paper: MTWA test can be performed on Atrial Fibrillation patients
with simultaneous A-V pacing: Editor Comment
·
Am J Cardiol 2006: Frequency and causes of implantable cardioverter-defibrillator
therapies: is device therapy proarrhythmic?
·
The Wall Street Journal (Nov. 1st ,2005):T Wave Test for Patients Facing Defibrillator Recall
·
MTWA Session at AHA 2005
with abstracts
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Predictive significance for sudden death of
microvolt-level T wave alternans in New York Heart Association class II
congestive heart failure patients ,A prospective study (International
Journal of Cardiology, Volume 105, Issue 1 , 20 October 2005)
·
ACC
2005 in Orlando: 7 new presentations
·
T-wave alternans could surpass LVEF as risk-stratifier
for ICD Implantation
·
Heart Rhythm 2005 Congress in New
Orleans: 20 Presentations and best abstracts
·
Clinical Utility of T-Wave
Alternans (ACCEL ONLINE)
·
The Lancet: T Wave Alternans Stratifies
Defibrillator Candidates in MADIT II type patients (Lancet 2003;362:91-92) Answers to Commentary
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JACC : SCD most likely to strike when LVEF doesn't meet criteria for
prophylactic ICD
·
Measurement of microvolt T-wave alternans, a new
arrhythmic risk stratification test, in Type 2 diabetic patients without
clinical cardiovascular disease (Diabetic Medicine Volume
23 Page 207 - February 2006)
·
MTWA in MADIT II type patients - Review
paper
·
paper on Circulation: Microvolt T-Wave Alternans as a Predictor of Ventricular
Tachyarrhythmias: A Prospective Study Using Atrial Pacing Circulation 2004;109 1854-1858
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NASPE 2004: Identification of
response to Resynchronization Therapy
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MTWA as
Predictor of Electrophysiology Testing Results in Professional Competitive
Athletes with 23 months follow up A.N.E 2004;9(3):1-6
·
NEW 6
presentations at AHA 2004 in New Orleans
·
Spontaneous Ventricular
Tachycardia and Fibrillation in a Patient with Positive MicroVolt T Wave
Alternans Test and Negative Electrophysiological Study (PACE 2004; 27:1-3)
·
The ALPHA study ( T
wave Alternans in Patients with Heart fAilure): rationale, design and endpoints
(Ital Heart J 2004; 5(8):587-592)
·
ACC 2004 : 14 New presentations with 8 Clinical abstracts
·
T Wave Alternans is a Predictor of Death in Patients with
Congestive Heart Failure ( International Journal of
Cardiology 2004; Vol 93 )
·
Use of BetaBlockers during MTWA Test in DCM patients:
Editor Comment
·
CARDIOSTIM 2004
MTWA
presentations with best abstracts
·
MTWA at NASPE 2003:- 5
new posters and one presentation
·
Low
value of EP testing in MADIT II population
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ESC 2003: The comparison of principal component analysis (PCA) ratio
with QT dispersion (QTd) and T-wave alternans in patients with old myocardial
infarction.
·
ACC2003 MADITII patients:-Late Breaking Clinical Trials,-“T-Wave
Alternans in Congestive Heart Failure,” Daniel Bloomfield, MD, Columbia
Presbyterian, New York City
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Repolarization Alternans: Implications
for the mechanism and prevention of sudden death, David Rosembaum
Cardiovascular Research Vol 57(3) (2003)(pdf file on request)
·
Usefulness of MTWA for
Prediction of VT Events in Patients with Dilated Cardiomyopathy: Results From a
Prospespective Study (JACC Vol 41, No 12, 2003) pdf files on
request
·
Intravenous Administration of Class I
Antiarrhythmic Drug Induced T Wave Alternans in an Asymptomatic Brugada
Syndrome Patient (PACE 2003
;26:1900-1903)
·
AHA 2003
11 presentations abstracts Microvolt
T-Wave Alternans Identifies MADIT II Type Patients at Low Risk of
Ventricular
Tachyarrhythmic Events (poster abstract)
·
Effects
of Selective Autonomic Blockade on T-Wave Alternans in Humans ( Circulation.
2002;105 105:837)
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Abstracts at ACC 2002
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“Clinical Use of Microvolt T-Wave Alternans Testing
in the Electrophysiology Laboratory”
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NASPE
2002 abstracts
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M T Wave Alternans as predictor of malignant
tachyarrhythmias in athletes (abstract) published on GIAC,
Vol 5, March 2002(*)
·
MTWA at
CARDIOSTIM 2002
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MTWA at European Congress of Cardiology
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MTWA and Tetralogy of Fallot J C E July 2002 (first page
pdf file)
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MTWA Short-Term Reproducibility JCE July 2002 (first page pdf file)
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Pathophysiological
Basis
JACC Vol 40 No2, 2002 (first page pdf file)
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MADIT II Type Patients Successfully Risk Stratified By
MTWA
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Alternans
of Action Potentials During Atrial Flutter as a Precursor to Atrial Fibrillation
(Circulation 2002;106:1968) abstract
·
AHA 2002 Scientific Session: 9 MTWA presentations
with
ABSTRACTS
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MTWA
is associated with left ventricle remodeling after myocardial infarction
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His Electrogram Alternans Reveal Dual Atrioventricular
Nodal Pathway Conduction During Atrial Fibrillation: The Role of Slow-Pathway
Modification
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ICD meta-analysis: Risk stratification
remains the challenge
·
Does Biventricular Pacing Decrease the Incidence of
Microvolt T-Wave Alternans? (Abstract)
·
JACC full text: Comparison of TWA, Signal averaged ECG and programmed
Stimulation for Arrhythmia risk Stratification (pdf); December 2000 (*)
·
Full text TWA
Review paper (**)
·
Micro TWA Study Matrix
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ABSTRACTS AC ACC 2001
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Hypertension: T Wave Alternans and V. Arrhythmias in Arterial
Hypertension; February 2001
ABSTRACT,FULL TEXT (pdf)(*)
·
NASPE
2001 TWA Abstracts
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TWA at Europace and ESC 2001 abstracts
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TWA in the Task Force Report on
Sudden Death of ESC
·
Clinical Usefullness of the Combination of TWA and
late Potentials for Identifying High Risk Patients with Moderately or Severely Impared
Left Ventricular Function ( first page pdf file) (*)
·
Predicting the
Recurrence of Ventricular Tachyarrhythmias from TWA on Antiarrhythmic
Pharmacotherapy (first page pdf file) (*)
·
Optimal Target Heart Rate for
Exercise-Induced T Wave Alternans, Nabil El-Sherif ANE 2001 First Page pdf file (*)
·
ABSTRACTS at AHA 2001
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MADIT II: Facts and MTWA Statements
·
New
2002 published papers (review):T
Wave Alternans as Predictor for Sudden Death After Myocardial Infarction ( AJC
Vol. 89 Jan 1, 2002) (*)Onset Heart Rate of Microvolt TWA Provides Clinical and
Prognostic Value in Nonischemic Dilated Cardiomyopathy (JACC Vol. 3, No 2,
2002)(*)Effect of Metropol and d,l-Sotalol on MicroVolt TWA (Vol. 38, No 7,
2001(*): (*)Pdf files
on request
·
Full Text T Wave Alternans overview paper ( published on
MASPE Journal)
(**)
·
ABSTRACTS AT ACC 2000
·
ABSTRACTS AT NASPE 2000
·
Abstract
and Editor C. of Buxton A. NEJM 2000 “ EPS to Identify Pts with CAD at
Risk for Sudden Death”
·
The Lancet
full text: Predictive value of TWA for arrhythmic events in patients
with Congestive Heart Failure (pdf ); August 2000 (*)
·
Updated: Medicare
Increases Payment for Microvolt T-Wave Alternans Test by 50%
·
ABSTRACTS AT ACC 99
·
PAPERS Published on
Circulation
·
ABSTRACTS AT NASPE 99
·
ABSTRACTS AT AHA 99
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Syncope Patients Dan Bloomfield full Abstract AHA 99
